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Frequent Asked Questions

Frequent Asked Questions

What is Biomaterials?

It is a synthetic material used to replace or repair missing part of a living system or to function in intimate contact with living tissue. It is a substance that has been engineered to take a form which, alone or as a part of a complex system is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure.*


What is Bioscaffold?

In regenerative medicine it s defined as “An artificial structure capable of supporting 3-D tissue formation.”  To allow bone formation a scaffold should allow: attachment, proliferation, migration, and phenotypic expression of bone cells leading to formation of new bone in direct apposition to the calcium Phosphate Ca-P biomaterial. *

A Bioscaffold allow cell attachment and migration, could deliver and retain cells and biochemical factors Enable diffusion of vital cell nutrients and expressed products could exert certain mechanical and biological influences to modify the behaviour of the cell phase differentiation.;


What is Biocomposite?

Biocomposites are multifunctional matrices derived by combining bioceramic materials and natural or synthetic polymers. They are intended to mimic the hybrid architecture of native bone . Biocomposites are non-toxic composites that are able to interact well with the living bone tissue in vivo and, ideally, contain one or more component(s) that stimulate(s) the healing process and uptake of the implant.


What is Osteoconduction?

 Is the ability of a porous scaffold to facilitate new bone formation by allowing bone cells to adhere, proliferate, and form extracellular matrix on its surface and pores

What is Bone Grafting?

Bone grafting is a surgical procedure that replaces missing bone (resulting from trauma, disease or congenital conditions) and restore bone strength and rigidity with either autogenous bone fragments (patient own bone), or bone graft substitutes, such cadaver bone (allograft) or synthetic (ex: Biomaterials, Bioscafold, Biocomposites, Bioceramics, Biopolymers or metal).

What are SVETOSS products are made of?

S-VETOSS and SVETOSS+ are the next generation, ultra-pure bone-like Bioactive Biomaterials that features a unique formulation meticulously engineered composition, surface and 3D structure to provide a safe, reliable, and effective bone tissue regeneration devices.


* S-VETOSS is a sterile bioceramics made of unlike osteoconductive Biphasic Calcium phosphate bioceramics. it contain 50% of Beta TCP (Beta Tricalcium phosphate) and 50% of HA (Hydroxyapatite). It is available in 4 different granules sizes and more than 12 SKUs to offer better choice and solutions for wide clinical surgical needs in dental and orthopedics surgeries suitable to almost all bone defect sizes and applications. S-VETOSS come in particle sizes ranging from 3mm to less than 0.5mm.

* SVETOSS+ is a polyphasic biocomposite made up of a carefully selected mix of osteoconductive bioceramics with selected granulometry. The bioceramics are embedded in a biocompatible and biodegradable gel to enhance bone healing. This combination results in a cohesive, easily injectable, and malleable bone graft implant that is easy to handle and has a strong stability at the surgical site. The sticky consistency allows for easy positioning, optimal contact with the bone surface, and adaptability to the shape of the defect for maximum bone-implant interface.

SVETOSS+ is the first CaP bioceramics bone graft putty for veterinary surgeons in North America, developed through close collaboration between Biomatcan's scientists and surgeons.

What is Autogenous Bone graft (Autograft)?​

The current Gold Standard is the autogenous bone graft which means that the graft originates from the patient’s bone tissue. Autogenous grafts can be cancellous or cortical depending on where the bone is harvested. They have the three properties of the ideal bone graft, especially the cancellous type. Other bone graft substitutes available on the market are usually osteoconductive (But DBM), rarely osteoinductive and not osteogenic.

What is Allograft and Xenograft? 

There are two main classes of bone substitutes based on source: Allografts and Xenografts. Allografts are bone substitutes that come from the same species as the recipient, while Xenografts are from different species. Both Allografts and Xenografts are derived from processed cadaver bone, while synthetic bone substitutes are not.

What are the risks associated with cadaveric bone grafts (ex: allografts, xenograft, DBM) ?

A common myth that persists is that Allogenic bone graft such Allografts and Xenografts, because they come from real bone, should be more natural than synthetic bone substitutes. This thinking extends to the belief that Allografts and Xenografts contain "growth factors" that actively promote bone formation and therefore, should be more effective at promoting bone growth.

The reality is that cadaveric bone must go through a harsh chemical and physical treatment process to mitigate the risk of infectious disease transmission. In the process, the bone becomes "denatured" and no living elements are left in it. All bioactive elements and growth factors are eliminated except for one, the DBM (Demineralized Bone Matrix), However the quality and consistency of DBM is variable due to the inconsistent quantity of BMP that can be detected within it. As each donor is different and the sterilisation and processing techniques vary widely the physical and biological characteristics of the material can markedly change between batches and at times the level of BMP has been detected to be lower than therapeutically useful  , Moreover DBM does not have any mechanical properties, and does not have an osteoconductive structure that would allow for effective bone growth through the matrix. DBM also does not fully resorb which affect the quality of the new bone.

 J Dent. 2016 May;48:1-8. doi: 10.1016/j.jdent.2016.03.010. Epub 2016 Mar 21. PMID: 27012858.

Bervan S, European Spine Journal. 2001; 10: S169-7

Is there any risks of disease transmission with SVETOSS’s products?

Svetoss’ products are sterile, made of pure and fully synthetics and biocompatible products and are free of any biological components. Thus there is no risk of any transmission disease.

S-VETOSS and SVETOSS+ guarantees unparalleled safety and efficacy for bone regeneration, without the risks associated with allografts, or the second surgery with autografts.


Are SVETOSS products causing any allergic reactions?

All component used in SVETOSS products formulations are approved by health authorities (for Human usage) and known for having history of safety in pharmaceutical and medical devices applications. Svetoss and SVETOSS+ have been tested for safety and efficacy as per the highest ISO standards.

S-VETOSS and SVETOSS+  are very safe and do not cause any allergic reactions.


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